Projects
How Somatostatin Might Drive Alzheimer’s Disease
We looked at a large gene database and saw that somatostatin (SST) levels are nearly 4× higher in Alzheimer’s brains. SST disrupts calcium balance in neurons, fueling production of the toxic amyloid‑β fragments. Our computer models suggest SST binds the pump‑regulator sarcolipin, further upsetting calcium control. Next steps: lab tests in cells and animal studies to see if blocking this interaction slows disease.